淋巴轉(zhuǎn)移是乳腺癌最常見的轉(zhuǎn)移途徑,腫瘤淋巴管生成可促進(jìn)惡性腫瘤細(xì)胞淋巴轉(zhuǎn)移。本項(xiàng)目根據(jù)podoplanin選擇性表達(dá)于淋巴管內(nèi)皮細(xì)胞(lymphatic endothelial cell, LEC)而在血管內(nèi)皮細(xì)胞不表達(dá)的特點(diǎn),選取podoplanin為淋巴管特異性標(biāo)記物,以金磁微粒(GoldMag)為磁共振成像(MRI)對(duì)比劑,GoldMag鰲合抗podoplanin抗體合成納米級(jí)的分子探針...
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